Neutrophilia independently predicts death in tuberculosis.

نویسندگان

  • David M Lowe
  • Asela K Bandara
  • Geoffrey E Packe
  • Richard D Barker
  • Robert J Wilkinson
  • Christopher J Griffiths
  • Adrian R Martineau
چکیده

Onno W. Akkerman, Richard van Altena, Theo Klinkenberg, Adrienne H. Brouwers, Alphons H.H. Bongaerts, Tjip S. van der Werf and Jan-Willem Alffenaar Dept of Pulmonology and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, Dept of Cardiothoracic Surgery, University of Groningen, University Medical Center Groningen, Groningen, Dept of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Dept of Radiology, University of Groningen, University Medical Center Groningen, Groningen, Dept of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, and Dept of Hospital and Clinical Pharmacy, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

رابطه شمارش گلبول های سفید با عملکرد بطن چپ در جریان انفارکتوس حاد قلبی

Background and purpose: Peripheral leukocytosis is a marker of inflammatory response in the early phase of acoute myocardial infarction(ÂMÏ). Role of peripheral leukocytosis and relative neutrophilia as a risk factor for early development of left ventricular systolic dysfunction (LVSD) is not established. Ôbjective of this study was to examine the relation between peripheral leukocyte differe...

متن کامل

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response

We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by which B cells regulate the host neutrophilic response upon exposure to mycobacteria and how neutrophilia may influence vaccine efficacy. To ad...

متن کامل

Rat neutrophils prevent the development of tuberculosis.

To understand the role of neutrophils in the development of rat tuberculosis in vivo, we utilized lipopolysaccharide (LPS)-induced neutrophilia in the lungs. LPS (50 micro g/ml) was administered intratracheally to male Fischer rats. Rats were then infected with Mycobacterium tuberculosis by an airborne route. Intratracheal injection of LPS significantly blocked the development of pulmonary gran...

متن کامل

Author's response to reviews Title: Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study Authors:

Title: Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study Authors:

متن کامل

Blood Neutrophil Counts in HIV-Infected Patients with Pulmonary Tuberculosis: Association with Sputum Mycobacterial Load

BACKGROUND Increasing evidence suggests that neutrophils play a role in the host response to Mycobacterium tuberculosis. We determined whether neutrophil counts in peripheral blood are associated with tuberculosis (TB) and with mycobacterial load in sputum in HIV-infected patients. METHODOLOGY/PRINCIPAL FINDINGS Adults enrolling in an antiretroviral treatment (ART) clinic in a Cape Town towns...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The European respiratory journal

دوره 42 6  شماره 

صفحات  -

تاریخ انتشار 2013